{"id":50,"date":"2022-11-11T09:54:59","date_gmt":"2022-11-11T14:54:59","guid":{"rendered":"https:\/\/dewpointx.com\/?page_id=50"},"modified":"2025-03-26T08:23:21","modified_gmt":"2025-03-26T12:23:21","slug":"science","status":"publish","type":"page","link":"https:\/\/dewpointx.com\/science\/","title":{"rendered":"Science"},"content":{"rendered":"
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\nA fully integrated discovery platform\n<\/h2>
\nWe integrate AI with state-of-the art interdisciplinary experimental technologies to ignite therapeutic possibilities in ways previously unimagined\n<\/div>\n<\/div><\/div>\n<\/section>
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\nScience\n<\/h1>
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\nCondensates: Cell biology 2.0\n<\/h2>
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\nAccording to the traditional view, the cell is compartmentalized by membrane-bound organelles such as the nucleus, mitochondria, and endoplasmic reticulum.\n<\/div>\n<\/div><\/div>\n<\/div>\n<\/div>
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\nBut we now understand that there are also many different membrane-less organelles - condensates, formed by a process called phase separation.\u00a0\n<\/div>\n<\/div><\/div>\n<\/div>\n<\/div>
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\nCondensates form and dissolve dynamically.\n<\/div>\n<\/div><\/div>\n<\/div>\n<\/div>
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\nTheir behavior is governed by multivalent interactions between proteins and nucleic acids. Condensates compartmentalize and concentrate molecules, enabling key biochemical processes.\n<\/div>\n<\/div><\/div>\n<\/div>\n<\/div>
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Aberrant condensates drive many diseases.<\/strong>
When something goes awry with a condensate\u2019s composition or behavior, we call it a condensatopathy.
Condensatopathies occur when biomolecules inappropriately form a compartment, fail to do so, or when proteins localize to the wrong condensate. The consequence can be a toxic gain of function and\/or a loss of function.<\/p>\n<\/div>\n<\/div><\/div>\n<\/div>\n<\/div>

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\nCondensate modifying drugs (c-mods) are uniquely designed to hit condensate targets.\n<\/div>\n<\/div><\/div>\n<\/div>\n<\/div>
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c-mods treat condensatopathies and prevent or reverse disease by:<\/strong>
\u2022 <\/strong>preventing harmful protein sequestration
\u2022 <\/strong>driving key components back into condensates
\u2022 <\/strong>restoring healthy condensate properties and function<\/p>\n<\/div>\n<\/div><\/div>\n<\/div>\n<\/div>\n <\/div>\n <\/div>\n\n

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\nKey publications\n<\/h2>
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